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US 5,635,404 AGranted
Applications of electrospray ionization mass spectrometry to neutral organic molecules including fullerenes
AssigneeNew York University
InventorStephen R. Wilson
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Abstract
Electrospray ionization mass spectroscopy (ESI-MS) methods, tagging reagents and novel compounds for labeling neutral compounds to provide ionized compounds for mass spectroscopy analysis, and novel compounds discovered using such EES-MS methods, including fulleroids
Claims9
A method of electrospray ion mass spectroscopy, ESI-MS, analysis of a neutral compound, comprising:
- reacting the neutral compound with a neutral tagging reagent capable of associating with a cation in solution to form a tagged compound;
- associating said tagged compound with a cation to form a product existing in solution as a charged compound capable of electrospray ionization;
- and
- performing ESI-MS on said charged compound,
- wherein the tagging reagent is selected from the group consisting of crown ethers, metal chelating agents and ligands for a metal.
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A method of electrospray ions mass spectroscopy, ESI-MS, analysis of a fulleroid compound, comprising:
- reducing the fulleroid compound with a metal to form a neutral fulleroid salt;
- reacting the fulleroid salt with a neutral tagging reagent capable of associating with a cation in solution to form a tagged compound;
- associating said tagged compound with an additional cation to form a product existing in solution as a charged compound capable of electrospray ionization;
- and
- performing ESI-MS on said charged compound,
- wherein the tagging reagent is:
- ##STR47##
4 more elements
Dependencies are inferred from the claim text.