Enhancement of nucleic acid transfer by coupling virus to nucleic acid via lipids
AssigneeVanderbilt University
InventorsAllen J. Naftilan, Rampyari Walia
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Abstract
This invention provides a method of enhancing the delivery of a nucleic acid into a cell, wherein a complex is formed comprising the nucleic acid, a cationic liposome, and a replication-deficient adenovirus, and the complex is administered to the cell to thereby enhance delivery of the nucleic acid into the cell. The method can be used to deliver the nucleic acid into a cell in a subject by administering the above complex into the subject.
Claims10
A method of enhancing the delivery of a nucleic acid into a cell in vitro, comprising
- a. forming a complex comprising the nucleic acid linked via a cationic liposome to a virus;
- and
- b. administering the complex to the cell, thereby enhancing the delivery of the nucleic acid into the cell.
A method of enhancing the delivery of a nucleic acid into a cell in vitro comprising administering a complex comprising the nucleic acid linked via a cationic liposome to a replication deficient virus to the cell, thereby enhancing the delivery of the nucleic acid into the cell.
A complex comprising a nucleic acid linked via a cationic liposome to an adenovirus.
Dependencies are inferred from the claim text.