Method of increasing the yield and heme saturation of cystathione .beta.-synthase
AssigneeThe Regents of the University of Colorado
InventorsJan P. Kraus, Vladimir Kery
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Abstract
A method of increasing the yield and heme saturation of hemoproteins in microorganisms. In this method, an effective amount of a heme precursor is added to a culture of hemoprotein producing microorganisms.
Claims3
A method of increasing the yield and heme saturation of cystathionine .beta.-synthase from a microorganism, which includes forming a cystathionine .beta.-synthase producing microorganism in a suitable cell culture medium, maintaining the microorganism under conditions conducive to cystathionine .beta.-synthase production, and isolating the cystathionine .beta.-synthase from the microorganism, wherein the improvement comprises:
- introducing a heme synthesis increasing heme precursor into the microorganism in an effective heme synthesis increasing amount.
Dependencies are inferred from the claim text.