BMP-15 compositions
AssigneesGenetics Institute, Inc., Vanderbilt University
InventorsAnthony J. Celeste, Jennifer L. Dube, Karen M. Lyons, Brigid Hogan
Life of this patent
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Abstract
Purified BMP-15-related proteins and processes for producing them are disclosed. DNA molecules encoding the BMP-15-related proteins are also disclosed. The proteins may be used in the treatment of bone and cartilage and/or other connective tissue defects and in wound healing and related tissue repair.
Claims17
An isolated DNA sequence encoding a BMP-15-related protein comprising a DNA sequence selected from the group consisting of:
- (a) nucleotides #490 or #634 to #1011 of SEQ ID NO:
- 1;
- (b) nucleotides #813 or #1002 to #1376 of SEQ ID NO:
- 3;
- and
- (c) sequences which hybridize to (a) or (b) under stringent hybridization conditions and encode a protein which exhibits the ability to form cartilage and/or bone and/or other connective tissue.
An isolated DNA sequence encoding BMP-15 protein comprising a DNA sequence selected from the group consisting of:
- (a) nucleotides encoding amino acids #-48 or #1 to #125 of SEQ ID NO:
- 2;
- (b) nucleotides encoding amino acids #-63 or #1 to #125 of SEQ ID NO:4;
- and
- (c) sequences which hybridize to (a) or (b) under stringent hybridization conditions and encode a protein which exhibits the ability to form cartilage and/or bone and/or other connective tissue.
An isolated DNA molecule having a sequence encoding a protein which is characterized by the ability to induce the formation of cartilage and/or bone and/or other connective tissue, said DNA molecule comprising a DNA sequence selected from the group consisting of:
- (a) nucleotide #634 to #1008 of SEQ ID NO:
- 1;
- and
- (b) nucleotide #1002 to #1376 of SEQ ID NO:
- 3;
- and
- (c) naturally occurring allelic sequences and equivalent degenerative codon sequences of (a) or (b).
An isolated DNA molecule encoding BMP-15 protein, said DNA molecule comprising nucleotide #1002 to #1376 of SEQ ID NO:
- 3.
A chimeric DNA molecule comprising a DNA sequence encoding a propeptide from a member of the TGF-.beta. superfamily of proteins linked in correct reading frame to a DNA sequence encoding a BMP-15-related polypeptide.
Dependencies are inferred from the claim text.