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US 5,635,351 AGranted
Genetic gain and loss in gliomas
AssigneeThe Regents of the University of California
InventorsBurt G. Feuerstein, Gayatry Mohapatra, Dong H. Kim
Life of this patent
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Abstract
The present invention provides chromosomal amplifications and deletions associated with neoplastic growth of gliomas. These amplifications and deletions may be used for detecting and grading gliomas. The invention also provides compositions for the detection of gliomas.
Claims63
A method of testing a sample for the possible presence of a glioma cell, said method comprising the steps of:
- providing a nucleic acid sample;
- and
- detecting, in said nucleic acid sample, an amplification or a deletion of a chromosomal region selected from the group consisting of an amplification in (1)(q21-23), an amplification in (1)(q32), an amplification in (1)(p36-pter), an amplification in (1)(p33-34.1), an amplification in (1)(p34.2-34.3), an amplification in (3)(q27-28), an amplification in (4)(p16), an amplification in (4)(q26-27), an amplification in (5)(p12-13), an amplification in (7)(p22), an amplification in (7)(q22), an amplification in (7)(q34-36), an amplification in (10)(q22), an amplification in (10)(q26), an amplification in (11)(q13), an amplification in (11)(q14-21), an amplification in (11)(q23), an amplification in (11)(p11.2-12), an amplification in (12)(p13.3), an amplification in (12)(p11.2-12.2), an amplification in (14)(q11.2-13), an amplification in (14)(q22-23), an amplification in (14)(q31-qter), an amplification in (15)(q13), an amplification in (15)(q15), an amplification in (17)(q24-25), an amplification in (17)(p11.2-12), an amplification in (19)(q13), an amplification in (19)(q13.4), an amplification in (20)(p11.2), an amplification in (20)(q13), an amplification in (X)(p22), an amplification in (X)(q27-28), an amplification in (Y)(p11.2-11.3), a deletion in (2)(p23-25), a deletion in (4)(q31.3-35), a deletion in (5)(q34-35), a deletion in (6)(q23-27), a deletion in (8)(q23-24.1), a deletion in (11)(q21-25), a deletion in (12)(q21-22), a deletion in (13)(q31-32), a deletion in (14)(q23-32), and a deletion in (21)(q21-22.1).
A method of testing a sample for the possible presence of a glioma cell, said method comprising the steps of:
- providing a nucleic acid sample;
- and
- detecting, in said nucleic acid sample, an amplification selected from the group consisting of an amplification (5)(q31.2), and an amplification at (7)(p22).
Dependencies are inferred from the claim text.