Stabilized composition of levothyroxine sodium medication and method for its production
AssigneeVintage Pharmaceuticals, Inc.
InventorsPieter J. Groenewoud, Hai Wang
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Abstract
The invention discloses a medication which requires the combination of levothyroxine sodium and potassium iodide, with the potassium iodide acting as a stabilizing excipient, the presence of which results in a more stable levothyroxine sodium medication and provides for longer shelf life of the medication. A method for manufacturing the disclosed medication is also provided.
Claims11
A method of making levothyroxine sodium medication by combining together:
- a. levothyroxine sodium mixed with a carrier;
- b. potassium iodide mixed with a carrier;
- c. a disintegrant, and
- d. a lubricant.
A method of making levothyroxine sodium medication by combining together:
- a. a mixture of levothyroxine sodium mixed with microcrystalline cellulose, said mixture comprised of 1.05% levothyroxine sodium and 98.95% microcrystalline cellulose;
- b. a second mixture of potassium iodide mixed with microcrystalline cellulose, said second mixture comprised of potassium iodide ranging from 0.1% to 0.7% and microcrystalline cellulose ranging from 99.9% to 99.3%;
- c. croscarmellose sodium;
- d. magnesium stearate, and
- e. colored dye.
A medication consisting of the combination of levothyroxine sodium with potassium iodide.
Dependencies are inferred from the claim text.