Process for liposomes or proliposomes
AssigneeHoffmann-La Roche Inc.
InventorsSabina Ganter, Karl M. Volker
Life of this patent
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Abstract
The invention relates to a process for the preparation of liposomes or proliposomes in which a mixture suitable for their preparation is milled in an agitator-ball mill.
Claims12
A process for preparing proliposomes, which comprises milling in an agitator-ball mill a mixture comprising 50 to 90% by weight of lecithin, 15 to 50% by weight of a solubilizer, 0 to 10% by weight of water, and 0 to 20% by weight of a compound to be incorporated, the milling being conducted at a milling speed and for a milling time effective to prepare proliposomes.
A process for preparing liposomes, which comprises milling in an agitator-ball mill a mixture comprising 1 to 30% by weight of lecithin, 1 to 15% by weight of a solubilizer, 35 to 95% by weight of water, and 0 to 5% by weight of a compound to be incorporated, the milling being conducted at a milling speed and for a milling time effective to prepare liposomes.
A process for preparing liposomes, which comprises:
- (a) milling in an agitator-ball mill a mixture comprising 50 to 90% by weight of lecithin, 15 to 50% by weight of a solubilizer, 0 to 10% by weight of water, and 0 to 20% by weight of a compound to be incorporated, the milling being conducted at a milling speed and for a milling time effective to prepare proliposomes in a milled mixture;
- (b) adding water to the milled mixture until the water content is between 35% and 95% by weight of the milled mixture to form a dilute mixture;
- and
- (c) milling in an agitator-ball mill the dilute mixture, the milling being conducted at a milling speed and for a milling time effective to prepare liposomes.
Dependencies are inferred from the claim text.