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US 5,635,205 AGranted
Pharmaceutical carrier system containing defined lipids
AssigneePharmacia & Upjohn Company
InventorsH.ang.kan Nyqvist, Gert Ragnarsson, Per Tingvall
Life of this patent
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Abstract
A lipid carrier system for a local anaesthetic comprising a defined lipid system of at least two lipid components wherein at least one of the lipid components is amphiphatic and polar and one is nonpolar is provided. The system may further contain a hydrophilic solvent and additives or matrices for adapting it for administering to mucous membranes and for transdermally administering.
Claims14
A carrier system comprising a defined lipid system of at least two lipid components and a local anaesthetic, wherein
- i) at least one of the lipid components is amphiphatic and polar in an amount of 5-50% (w/w) of the lipid system, and
- ii) at least one of the lipid components is nonpolar and corresponding in an amount of 50 to 95% (w/w), and comprises a mixture of monoglycerides wherein the fatty acid portion of each of said monoglycerides is from an acid selected from the group consisting of 8:0 caprylic acid, and 10:0 capric acid, and wherein discrete lipid particles are formed spontaneously when interacting with excess aqueous medium.
Dependencies are inferred from the claim text.