Transdermal device having decreased delamination
AssigneeAlza Corporation
InventorsRobert M. Gale, Eun Soo Lee
Life of this patent
Estimating the term…
Abstract
A device for the transdermal administration of a drug comprising a microporous tie layer located between the drug reservoir and the contact adhesive. The tie layer eliminates blooming and delamination and has no appreciable adverse effect on either the drug flux or release rate from the device.
Claims13
A transdermal device including a non-aqueous reservoir containing a drug and a non-ionic surfactant for the transdermal administration of a drug at a therapeutically effective rate, which device comprises:
- a) a non-aqueous reservoir comprising a therapeutically effective amount of a drug and a skin permeation-enhancing amount of a non-ionic surfactant;
- b) a non-rate controlling tie layer on the skin-proximal surface of the reservoir that is formed from a material having low or negligible solubility for the non-ionic surfactant and the drug and is sufficiently porous so as not to affect, to a rate-controlling extent, the drug flux or drug release rate from the device;
- c) a backing on the skin-distal surface of the reservoir;
- and
- d) means for maintaining the reservoir in drug- and permeation enhancer mixture-transmitting relation with the skin on the skin-proximal surface of the tie layer.
A transdermal device including a non-aqueous reservoir containing a drug and a non-ionic surfactant for the transdermal administration of a drug at a therapeutically effective rate, which device comprises:
- a) a non-aqueous first reservoir comprising a therapeutically effective amount of a drug and a non-ionic surfactant skin permeation enhancer;
- b) a second non-aqueous reservoir comprising drug at or below saturation and an excess of the non-ionic surfactant permeation enhancer;
- a rate-controlling membrane between the first and second reservoir;
- d) a backing on the skin-distal surface of the second reservoir;
- e) a non-rate controlling tie layer on the skin proximal surface of the first reservoir that is formed from a material having low or negligible solubility for the non-ionic surfactant and the drug and is sufficiently porous so as not to affect, to a rate-controlling extent, the drug flux or drug release rate from the device;
- and
- f) means for maintaining the first and second reservoirs in drug- and permeation enhancer mixture-transmitting relation with the skin on the skin-proximal surface of the tie layer.
Dependencies are inferred from the claim text.