Taste-making compositions of ranitidine
AssigneeGlaxo Group Limited
InventorsStephen J. Douglas, Jill Evans
Life of this patent
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Abstract
This invention relates to a composition which is substantially free of the bitter taste associated with ranitidine and comprises: a) a dispersion of lipid coated particles of ranitidine or a physiologically acceptable salt thereof in a non-aqueous vehicle; b) particles comprising ranitidine or a physiologically acceptable salt thereof incorporated into a core and coated with a lipid coating; c) lipid coated particles of a form of ranitidine which is poorly soluble in water; and processes for the preparation thereof and pharmaceutical compositions thereof.
Claims17
A composition which is substantially free of the bitter taste associated with ranitidine and comprises particles having a core and a lipid coating around the core wherein the core comprises a dispersion of ranitidine, or a physiologically acceptable salt thereof, in a binder selected from the group consisting of polyvinylpyrrolidone, acrylate polymers and cellulose-based polymers and wherein the lipid coating comprises lipids selected from the group consisting of fatty acids or monohydric alcohols thereof, fixed oils, fats, sterols, phospholipids, glycolipids and mixtures thereof.
Dependencies are inferred from the claim text.