Pharmaceutical compositions containing IL-6
AssigneeApplied Research Systems ARS Holding N.V.
InventorsFabrizio Samaritani, Filippo Rendina
Life of this patent
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Abstract
Pharmaceutical compositions based on Interleukin-6 (IL-6) stabilized with non reducing sugars, such as sucrose and trehalose. The compositions may also contain an amino acid or human albumin as an excipient. The formulation is particularly suitable for the stabilization of recombinant IL-6 freeze-dried powder.
Claims17
A pharmaceutical composition containing an intimate solid mixture of Interleukin-6 (IL-6) and a stabilizing quantity of a nonreducing sugar as stabilizing agent either alone or in conjuction with excipients, said intimate solid mixture being a freeze-dried powder.
In a process for the preparation of a solid pharmaceutical composition comprising the preparation of an aqueous solution of the components for the composition, distribution of the solution into containers and drying or freeze-drying of the solution in the containers, the improvement wherein the components are a mixture of Interleukin-6 and a stabilizing quantity of a non-reducing sugar.
In a process for the preparation of a solid pharmaceutical composition comprising preparing an aqueous solution of the components for the pharmaceutical composition, drying or freeze-drying the aqueous solution and distributing the solid mixture obtained into containers, the improvement wherein the components are a mixture of Interleukin-6 and a stabilizing quantity of a non-reducing sugar.
Dependencies are inferred from the claim text.