Aerosol drug formulations containing vegetable oils
AssigneeAbbott Laboratories
InventorsAkwete L. Adjei, Pramod K. Gupta, Dennis Y. Lee
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Abstract
Pharmaceutical compositions for aerosol delivery comprising (a) a medicament, (b) a non-chlorofluorocarbon propellant, and (c) a vegetable oil or a pharmaceutically acceptable derivative thereof, as well as a method for preparing such compositions in which unwanted aggregation of the medicament is prevented without the use of surfactants, protective colloids or cosolvents.
Claims15
A pharmaceutical composition for aerosol delivery comprising a medicament suitable for pulmonary delivery, a halogenated alkane propellant and a biocompatible C.sub.16+ unsaturated vegetable oil having an HLB value of less than 14, wherein the medicament is present in a concentration of from about 0.05% to about 5% by weight, the vegetable oil is present in a concentration of from 0.001% to about 10% by weight, the halogenated alkane propellant is selected from the group consisting of HCFC 123, HCFC 124, HCFC 141b, HCFC 225, HCFC 125, perfluorodimethylcylobutane, DYMEL 152a, HFC 134a and HFC 227ea and the biocompatible C.sub.16+ unsaturated vegetable oil is selected from olive oil, safflower oil and soybean oil.
Dependencies are inferred from the claim text.