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US 5,635,159 AGranted
Aerosol drug formulations containing polyglycolyzed glycerides
AssigneeAbbott Laboratories
InventorsMou-Ying Fu Lu, Akwete L. Adjei, Pramod K. Gupta
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AssigneeAbbott Laboratories
InventorsMou-Ying Fu Lu, Akwete L. Adjei, Pramod K. Gupta
Estimating the term…
Pharmaceutical compositions for aerosol delivery comprising (a) a medicament, (b) a non-chlorofluorocarbon propellant, and (c) a polyglycolized glyceride having a hydrophilic lipophilic balance of between and including 6 and 14, wherein the medicament is present in a concentration of between about 0.05% and about 5% by weight and the polyglycolized glyceride is present in a concentration of between about 0.001% and about 10% by weight, the nonchlorofluorocarbon propellant is selected from the group consisting of HCFC 123, HCFC 124, HCFC 141b, HCFC 225, HCFC 125, FC-C 51-12, DYMEL A, DYMEL 152a, HFC 134a and HFC 227ea in which unwanted aggregation of the medicament is prevented without the use of surfactants, protective colloids or cosolvents.
A pharmaceutical composition for aerosol delivery consisting essentially of a medicament, a non-chlorofluorocarbon propellant as the sole propellant, and a polyglycolized glyceride having a hydrophilic lipophilic balance of between and including 6 and 14, wherein the medicament is present in a concentration of between about 0.05% and about 5% by weight and the polyglycolized glyceride is present in a concentration of between about 0.001% and about 10% by weight, the non-chlorofluorocarbon propellant is selected from the group consisting of HCFC 123, HCFC 124, HCFC 141b, HCFC 225, HCFC 125, perfluorodimethylcyclobutane DYMEL A, DYMEL 152a, HFC 134a and HFC 227ea, provided said composition does not contain a surfactant, protective colloid or cosolvent.
Dependencies are inferred from the claim text.