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US 5,635,156 AGranted
Non-lethal methods for conditioning a recipient for bone marrow transplantation
AssigneeUniversity of Pittsburgh
InventorSuzanne T. Ildstad
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AssigneeUniversity of Pittsburgh
InventorSuzanne T. Ildstad
Estimating the term…
The present invention relates to non-lethal methods of conditioning a recipient for bone marrow transplantation. In particular, it relates to the use of nonlethal doses of total body irradiation, total lymphoid irradiation cell type-specific antibodies, especially antibodies directed to bone marrow stromal cell markers, cytotoxic drugs, or a combination thereof. The methods of the invention have a wide range of applications, including, but not limited to, the conditioning of an individual for hematopoietic reconstitution by bone marrow transplantation for the treatment of hematologic malignancies, hematologic disorders, autoimmunity, infectious diseases such as acquired immunodeficiency syndrome, and the engraftment of bone marrow cells to induce tolerance for solid organ, tissue and cellular transplantation.
A method for conditioning a recipient for bone marrow transplantation comprising subjecting the recipient to treatment with a non-lethal dose of total body irradiation, an alkylating agent and an antibody or an active fragment thereof, followed by transplantation with a donor cell preparation containing hematopoietic stem cells which are not compatible with the recipient at the major histocompatibility complex, to achieve stable engraftment of donor hematopoietic stem cells.
Dependencies are inferred from the claim text.