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US 5,633,395 AGranted
Chemically-defined non-polymeric valency platform molecules and conjugates thereof
AssigneeLa Jolla Pharmaceutical Company
InventorsStephen M. Coutts, David S. Jones, Douglas A. Livingston, Lin Yu
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Abstract
Chemically-defined, non-polymeric valency platform molecules and conjugates comprising chemically-defined valency platform molecules and biological or chemical molecules including polynucleotide duplexes of at least 20 base pairs that have significant binding activity for human lupus anti-dsDNA autoantibodies.
Claims1
A chemically-defined, non-polymeric valency platform molecule of the formula:
- ##STR13## wherein G.sup.[7] is --CH.sub.2 CH.sub.2 --O--CH.sub.2 CH.sub.2 --O--CH.sub.2 CH.sub.2 --;
- Q.sup.[7] is --CH.sub.2 CH.sub.2 --NH--C(.dbd.O)--(CH.sub.2).sub.5 --NH--C(.dbd.O)--;
- each of the (p.sup.[7] x n.sup.[7]) moieties shown as T.sup.[7] is R.sup.ALK X;
- each X is independently a halogen of atomic number greater than 16 and less than 54 or other good leaving group;
- each R.sup.ALK is independently a linear, branched, or cyclic alkyl (1-20C) group;
- n.sup.[7] =2;
- and
- p.sup.[7] =2.
5 more elements
Dependencies are inferred from the claim text.