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US 5,633,392 AGranted
Estrenes for inducing hypothalamic effects
AssigneePherin Corporation
InventorsDavid L. Berliner, Nathan W. Adams, Clive L. Jennings-White
Life of this patent
Estimating the term…
Abstract
The invention relates to estrene steroids, which bind to neuroepithelial receptors. The steroid is preferably administered in the form of a pharmaceutical composition containing one or more pharmaceutically acceptable carriers.
Claims8
A steroid compound of the formula ##STR70## wherein R.sub.1 is methylene;
- R.sub.2 is absent or is hydrogen or methyl;
- R.sub.3 is oxo, hydroxy, lower alkoxy, lower acyloxy, benzoyl, cypionyl, glucuronide or sulfonyl;
- R.sub.4 is hydrogen, hydroxy, lower alkoxy, lower acyloxy, oxo or halo;
- R.sub.5 is absent or is hydrogen, hydroxy, lower alkoxy or lower acyloxy;
- R.sub.6 is a hydrogen or a halo;
- and "a" represents optional aromatic unsaturation of ring A of said steroid, or "b", "c", and "d" are each optional double bonds;
- and "e", "f", "g", "h", "i" and "j" are each optional double bonds;
- with the proviso that:
- when "a" is present, "j", "i", "e", "f" and "g" are all absent, R.sub.2 is methyl, "h" is present or absent, then R.sub.3 cannot be hydroxy.
6 more elements
Dependencies are inferred from the claim text.