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US 5,633,388 AGranted
Compounds, compositions and methods for treatment of hepatitis C
AssigneeViroPharma Incorporated
InventorsGuy D. Diana, Thomas R. Bailey
Life of this patent
Estimating the term…
Abstract
Heterocyclic substituted carboxamides are useful in prophylaxis and treatment of hepatitis C virus infections.
Claims23
A compound having the formula:
- ##STR16## wherein Q is an arylene moiety of the formula:
- ##STR17## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are the same or different and represent substituents selected from the group consisting of hydrogen, alkyl (C.sub.1 -C.sub.6), halogen, hydroxy, alkoxy, carboxy, carbalkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, amino, acetamido, sulfonamido, alkylamino, dialkylamino and NO.sub.2 ;
- R and R' are the same or different and represent hydrogen or an alkyl (C.sub.1 -C.sub.6) group;
- Y and Y' represent the same or different divalent moieties selected from the group consisting of alkylene (C.sub.3 -C.sub.5) and phenylene, said Y and Y' moieties being unsubstituted or substituted with at least one alkyl group (C.sub.1 -C.sub.6);
- Z and Z' represent the same or different substituent having the formula:
- ##STR18## wherein R.sub.5 represents a substituent selected from the group consisting of hydrogen, alkyl (C.sub.1 -C.sub.6) and acyl, and each R.sub.6 is the same or different and represents a substituent selected from the group consisting of hydrogen, alkyl (C.sub.1 -C.sub.6), halogen, hydroxy, alkoxy, carboxy, carbalkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, amino, acetamido, sulfonamido, alkylamino, dialkylamino and NO.sub.2, with m being 1-4, and the isomers and pharmaceutically acceptable salts of said compound.
3 more elements
A compound having the formula:
- ##STR19## wherein Q is a divalent moiety selected from the group consisting of straight or branched, unsubstituted or substituted C.sub.1 -C.sub.12 alkylene, straight or branched, unsubstituted or substituted C.sub.2 -C.sub.12 alkenylene, straight or branched, unsubstituted or substituted C.sub.1 -C.sub.12 alkylene interrupted with oxygen, nitrogen or sulfur, straight or branched, unsubstituted or substituted C.sub.2 -C.sub.12 alkenylene interrupted with oxygen, nitrogen or sulfur, said alkylene and alkenylene moiety substituents being selected from at least one of the group consisting of alkyl (C.sub.1 -C.sub.6), amino, alkylamino, dialkylamino or acetamido;
- R and R' are the same or different and represent hydrogen or an alkyl (C.sub.1 -C.sub.6) group;
- Y and Y' represent the same or different divalent moieties selected from the group consisting of alkylene (C.sub.3 -C.sub.5) and phenylene, said Y and Y' moieties being unsubstituted or substituted with at least one alkyl group (C.sub.1 -C.sub.6);
- Z and Z' represent the same or different substituent having the formula:
- ##STR20## wherein R.sub.5 represents a substituent selected from the group consisting of hydrogen, alkyl (C.sub.1 -C.sub.6) and acyl, and each R.sub.6 is the same or different and represents a substituent selected from the group consisting of hydrogen, alkyl (C.sub.1 -C.sub.6), halogen, hydroxy, alkoxy, carboxy, carbalkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, amino, acetamido, sulfonamido, alkylamino, dialkylamino and NO.sub.2, with m being 1-4, and the isomers and pharmaceutically acceptable salts of said compound.
2 more elements
Dependencies are inferred from the claim text.