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US 5,633,349 AGranted
Method of inactivating prions (slow viruses) conventional viruses and other infections agents in biological material
OwnerHerwig Reichlinventor
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OwnerHerwig Reichlinventor
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A method for the inactivation of prions, viruses and other infectious agents, which might be present in a biological raw material (e.g. plasma for the preparation of albumin), leaving the desired biological product (e.g. BSA, HSA) intact. To achieve this, the biological raw material is treated with a chaotropic agent, e.g. urea or siodium thiocyanate for approx. 18 hours. Before this, a detergent, e.g. sodium dodecyl sulfate, as well as ethanol or methanol can be added, and the solution can be heated to 70.degree. C. and kept at this temperature for 30 minutes. After cooling and acidification, denatured globulins can be removed. By modifications of this process (e.g. different concentrations, pH-values, temperatures etc.) a wide range of biological products (serum, plasma, proteins, peptides, gangliosides etc.) can be treated and rendered free of viruses, prions and all other infectivity.
In a process for treating a biological or biogenic material derived from serum or plasma and containing an infectious agent, the improvement which comprises destroying prions in said biological or biogenic material by treating the biological or biogenic material with urea or a thiocyanate as a chaotropic agent for a minimum of 12 hours at a temperature of 20.degree. to 25.degree. C. and removing the chaotropic agent from the biological or biogenic material following the treatment.
A process for treating a biological or a biogenic material derived from serum or plasma and which contains an infectious agent, said process comprising, in the following sequence, the steps of:
Dependencies are inferred from the claim text.