Cytoprotective wound healing compositions and methods for preparing and using same
AssigneeWarner-Lambert Company
InventorAlain Martin
Life of this patent
Estimating the term…
Abstract
This invention pertains to therapeutic cytoprotective-wound healing compositions. The compositions comprise a cytotoxic agent and a therapeutic wound healing composition. In one embodiment the wound healing composition comprises (a) pyrvuate: (b) an antioxidant; and (c) a mixture of saturated and unsaturated fatty acids. In another embodiment the wound healing composition comprises (a) pyruvate; and, (b) an antioxidant. The therapeutic cytoprotective-wound healing compositions may be utilized in a wide variety of pharmaceutical products. This invention also relates to methods for preparing and using the therapeutic cytoprotective-wound healing compositions and the pharmaceutical products in which the compositions may be used.
Claims20
A therapeutic cytoprotective-wound healing composition for protecting and reducing injury to mammalian cells which comprises a therapeutically effective amount of a cytotoxic agent and a wound healing composition, wherein the wound healing composition comprises:
- (a) pyruvate selected from the group consisting of pyruvic acid, pharmaceutically acceptable salts of pyruvic acid, and mixtures thereof;
- (b) an antioxidant;
- and
- (c) a mixture of saturated and unsaturated fatty acids wherein the fatty acids are those fatty acids required for the resuscitation of injured mammalian cells;
- wherein components a, b, and c are present in amounts sufficient to synergistically enhance wound healing.
A method for preventing and reducing injury to mammalian cells from a cytotoxic agent which comprises (the steps of) administering to a mammal in need thereof:
- a therapeutic cytoprotective-wound healing composition which comprises:
- (1) a therapeutically effective amount of a cytotoxic agent;
- and
- (2) a wound healing composition which comprises:
- (a) pyruvate selected from the group consisting of pyruvic acid, pharmaceutically acceptable salts of pyruvic acid, and mixtures thereof;
- (b) an antioxidant;
- and
- (c) a mixture of saturated and unsaturated fatty acids wherein the fatty acids are those fatty acids required for the resuscitation of injured mammalian cells;
- wherein components a,b, and c are present in amounts sufficient to synergistically enhance wound healing.
An augmented cytoprotective-wound healing composition which comprises:
- (A) a therapeutic cytoprotective-wound healing composition which comprises:
- (1) a therapeutically effective amount of a cytotoxic agent;
- and
- (2) a wound healing composition which comprises:
- (a) pyruvate selected from the group consisting of pyruvic acid, pharmaceutically acceptable salts of pyruvic acid, and mixtures thereof;
- (b) an antioxidant;
- and
- (c) a mixture of saturated and unsaturated fatty acids wherein the fatty acids are those fatty acids required for the repair of cellular membranes and resuscitation of mammalian cells;
- wherein components a, b, and c are present in amounts sufficient to synergistically enhance wound healing;
- and
- (B) a medicament useful for treating wounds.
A method for preventing and reducing injury to mammalian cells from a cytotoxic agent with an augmented cytoprotective-wound healing composition which comprises administering to a mammal in need thereof:
- a therapeutic augmented cytoprotective-wound healing composition which comprises:
- (1) a therapeutically effective amount of a cytotoxic agent;
- (2) a wound healing composition which comprises:
- (a) pyruvate selected from the group consisting of pyruvic acid, pharmaceutically acceptable salts of pyruvic acid, and mixtures thereof;
- (b) an antioxidant;
- and
- (c) a mixture of saturated and unsaturated fatty acids wherein the fatty acids are those fatty acids required for the resuscitation of injured mammalian cells;
- wherein components a,b, and c are present in amounts sufficient to synergistically enhance wound healing, and
- (3) a medicament useful for treating wounds.
A cytoprotective-wound healing pharmaceutical composition which comprises:
- (A) a therapeutic cytoprotective wound-healing composition which comprises:
- (1) a therapeutically effective amount of a cytotoxic agent;
- and
- (2) a wound healing composition which comprises:
- (a) pyruvate selected from the group consisting of pyruvic acid, pharmaceutically acceptable salts of pyruvic acid, and mixtures thereof;
- (b) an antioxidant;
- and
- (c) a mixture of saturated and unsaturated fatty acids wherein the fatty acids are those fatty acids required for the repair of cellular membranes and resuscitation of mammalian cells;
- wherein components a, b, and c are present in amounts sufficient to synergistically enhance wound healing;
- and
- (B) a pharmaceutically acceptable carrier selected from the group consisting of pharmaceutical appliances, bioadhesives, and occlusive vehicles.
A timed-release cytoprotective-wound healing composition for selectively protecting non-cancerous mammalian cells in the presence of cancerous mammalian cells from an anticancer cytotoxic agent which comprises:
- (A) a wound healing composition ((I.A)) in immediate release form comprising:
- (a) pyruvate selected from the group consisting of pyruvic acid, pharmaceutically acceptable salts of pyruvic acid, and mixtures thereof;
- (b) an antioxidant;
- and
- (c) a mixture of saturated and unsaturated fatty acids wherein the fatty acids are those fatty acids required for the repair of cellular membranes and resuscitation of mammalian cells;
- wherein components a, b, and c are present in amounts sufficient to synergistically enhance wound healing;
- and
- (B) an anticancer cytotoxic agent in timed-release form;
- wherein the wound healing composition is released substantially immediately and the anticancer cytotoxic agent is released after a period of time sufficient such that the cancerous cells have substantially metabolized the wound healing composition and the non-cancerous cells have not substantially metabolized the wound healing composition.
Dependencies are inferred from the claim text.