Indoline derivatives, method of preparation and use
AssigneeGlaxo Group Limited
InventorsPeter C. North, Malcolm C. Carter
Life of this patent
Estimating the term…
Abstract
A compound of formula (I) ##STR1## wherein, R.sup.1 is hydrogen, halogen or C.sub.1-6 alkyl; R.sup.2 is a group of formula --CR.sup.3 R.sup.4 (CH.sub.2).sub.p NR.sup.5 COR.sup.6 ; R.sup.3, R.sup.4 and R.sup.5, which may be the same or different, are hydrogen or C.sub.l-6 alkyl; R.sup.6 is C.sub.1-6 alkyl or C.sub.3-7 cycloalkyl; n is an integer of 2, 3 or 4; p is an integer of 1, 2, 3 or 4; and pharmaceutically acceptable salts and solvates thereof. A compound of formula (I) is useful in the treatment of conditions associated with a disturbed functioning of the melatonin system.
Claims17
A compound of formula (I) ##STR16## wherein R.sup.1 is hydrogen, halogen or C.sub.1-6 alkyl;
- R.sup.2 is a group of formula --CR.sup.3 R.sup.4 (CH.sub.2).sub.p NR.sup.5 COR.sup.6 ;
- R.sup.3, R.sup.4 and R.sup.5, which may be the same or different, are hydrogen or C.sub.1-6 alkyl;
- R.sup.6 is C.sub.1-6 alkyl or C.sub.3-7 cycloalkyl;
- n is an integer of 2, 3 or 4;
- p is an integer of 1, 2, 3 or 4;
- and pharmaceutically acceptable salts and solvates thereof.
A compound of formula (Ia) ##STR17## wherein, R.sup.1 is hydrogen, halogen or C.sub.1-6 alkyl;
- R.sup.2 is a group of formula --CR.sup.3 R.sup.4 (CH.sub.2).sub.p NR.sup.5 COR.sup.6 ;
- R.sup.3, R.sup.4 and R.sup.5, which may be the same or different, are hydrogen or C.sub.1-6 alkyl;
- R.sup.6 is C.sub.1-6 alkyl or C.sub.3-7 cycloalkyl;
- p is an integer of 1, 2, 3 or 4;
- and pharmaceutically acceptable salts and solvates thereof.
N-[2-(2,3,8,9-Tetrahydro-7H-pyrano[2,3-g]indol-1-yl)-ethyl]-acetamide;
- N-[2-(5-Chloro-2,3,7,8-tetrahydro-1H-furo[2,3-g]indol-1-yl)-ethyl]-acetamid e;
- Cyclopropanecarboxylic acid [2-(2,3,7,8-tetrahydro-1H-furo[2,3-g]indol-1-yl)-ethyl]-amide;
- and pharmaceutically acceptable salts and solvates thereof.
N-[2-(2,3,7,8-Tetrahydro-1H-furo[2,3-g]indol-1-yl)-ethyl]-acetamide and pharmaceutically acceptable salts and solvates thereof.
Dependencies are inferred from the claim text.