Azacyclic compounds compositions containing them and their use as tachykinin antagonists

A compound of formula (I), or a salt thereof:

• ##STR14## wherein n is 3 and where any carbon atom of (CH.sub.2).sub.n may be substituted by R.sup.4 and/or R.sup.5 ;
• X represents O or S;
• R.sup.1 represents (CH.sub.2).sub.q phenyl, wherein q is 0, 1, 2 or 3, which may be optionally substituted in the phenyl ring by 1, 2 or 3 groups selected from C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, halo, cyano, nitro, trifluoromethyl, trimethylsilyl, --OR.sup.a, SR.sup.a, SOR.sup.a, SO.sub.2 R.sup.a, --NR.sup.a R.sup.b, --NR.sup.a COR.sup.b, --NR.sup.a CO.sub.2 R.sup.b, --CO.sub.2 R.sup.a and --CONR.sup.a R.sup.b ;
• R.sup.2 represents aryl selected from phenyl and naphthyl;
• heteroaryl selected from indazolyl, thienyl, furyl, pyridyl, thiazolyl, tetrazolyl and quinolyl;
• moiety may be substituted by C.sub.1-6 alkyl, C.sub.1-6 alkoxy halo benzhydryl;
• or benzyl;
• wherein each aryl or heteroaryl or trifluoromethyl;
• R.sup.4 and R.sup.5 each independently represent H, halo, C.sub.1-6 alkyl, CO.sub.2 .sup.R.sup.a or CONR.sup.a R.sup.b or R.sup.4 and R.sup.5 together form an oxo;
• R.sup.6 represents H or C.sub.1-6 alkyl;
• R.sup.7 represents C.sub.1-6 alkyl or phenyl optionally substituted by 1, 2 or 3 groups selected from C.sub.1-6 alkyl.sub., C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, halo, cyano, nitro, trifluoromethyl, trimethylsilyl, --OR.sup.a, SR.sup.a, SOR.sup.a, SO.sub.2 R.sup.a, NR.sup.a R.sup.b, --NR.sup.a COR.sup.b, --NR.sup.a CO.sub.2 R.sup.b, --CO.sub.2 R.sup.a and --CONR.sup.a R.sup.b ;
• R.sup.8 represents H, COR.sup.a, CO.sub.2 R.sup.a, COCONR.sup.a R.sup.b, COCO.sub.2 R.sup.a, C.sub.1-6 alkyl optionally substituted by a group selected from (CO.sub.2 R.sup.a, CONR.sup.a R.sup.b, hydroxy, cyano, COR.sup.a, NR.sup.a R.sup.b, C(NOH)NR.sup.a R.sup.b, CONHphenyl(C.sub.1-4 alkyl), COCO.sub.2 .sup.R.sup.a, CONRHNR.sup.a R.sup.b, C(S)NR.sup.a R.sup.b, CONR.sup.a C.sub.1-6 alkylR.sup.12, CONR.sup.13 C.sub.2-6 alkynyl, CONR.sup.13 C.sub.2-6 alkenyl, COCONR.sup.a R.sup.b, CONR.sup.a C(NR.sup.b)NR.sup.a R.sup.b, CONR.sup.a heteroaryl, wherein heteroaryl is defined above, and phenyl optionally substituted by one or more substituents selected from C.sub.1-6 alkyl, C.sub.1-6 alkoxy, halo and trifluoromethyl) or C.sub.1-6 alkyl, optionally substituted by oxo, substituted by an aromatic heterocyclic group selected from thienyl, furyl, pyrrolyl, pyridyl, pyrazolyl, triazolyl, tetrazolyl, thiazolyl, pyrazinyl, pyridazinyl, oxazolyl, oxadiazolyl, thiadiazolyl, isoxazolyl, quinolyl, isothiazolyl, imidazolyl, benzimidazolyl, benzoxazolyl, benzothiophenyl, benzofuranyl and indolyl, which group is optionally substituted by C.sub.1-6 alkyl, C.sub.1-6 alkxy, oxo, thioxo, halo, trifluoromethyl, N.sup.R.sup.a R.sup.b, NR.sup.a COR.sup.b, CONR.sup.a R.sup.b, CO.sub.2 R.sup.a, SO.sub.2 R.sup.a and CH.sub.2 OR.sup.a, where R.sup.a and R.sup.b are as previously defined;
• R.sup.a and R.sup.b each independently represent H, C.sub.1-6 alkyl, trifluoromethyl or phenyl optionally substituted by C.sub.1-6 alkyl, halo or trifluoromethyl;
• R.sup.12 represents OR.sup.a, CONR.sup.a R.sup.b or heteroaryl;
• and
• R.sup.13 represents H or C.sub.1-6 alkyl.