Pyridine compounds for treating leukotriene-related diseases

A compound of formula I ##STR9## or an N-oxide, or a pharmaceutically acceptable salt where Z is NH, or NCH.sub.3,

• m is 0-5;
• R is C.sub.1 to C.sub.20 -aliphatic, unsubstituted or substituted phenyl C.sub.1 to C.sub.10 -aliphatic where substituted phenyl has one or more radicals selected from the group consisting of lower alkoxy, lower alkyl, trihalomethyl, and halo, or R is C.sub.1 to C.sub.20 -aliphatic-O--, or R is unsubstituted or substituted phenyl C.sub.1 to C.sub.10 -aliphatic-O-- where substituted phenyl has one or more radicals selected from the group consisting of lower alkoxy, lower alkyl, trihalomethyl, and halo;
• R.sub.1 is -(C.sub.1 to C.sub.5 aliphatic)R.sub.4,-(C.sub.1 to C.sub.5 aliphatic)CHO, -(C.sub.1 to C.sub.5 aliphatic)CH.sub.2 OR.sub.8,--R.sub.4, --CH.sub.2 OH, or CHO;
• R.sub.2 is H, halo, lower alkyl, lower alkoxy, --CN, --(CH.sub.2).sub.n R.sub.4, --CH(NH.sub.2)(R.sub.4), or --(CH.sub.2).sub.n R.sub.9 where n is 0-5 and where R.sub.9 is --N(R.sub.7).sub.2 where each R.sub.7 is independently H, or an aliphatic group of 1 to 10 carbon atoms, or acyl of 1-6 carbon atoms, or a cycloalkyl-(CH.sub.2).sub.n -group of 4 to 10 carbons where n is 0-3, or both R.sub.7 groups form a ring having 4 to 6 carbons;
• or
• R.sub.3 is hydrogen, lower alkyl, lower alkoxy, halo, --CN, R.sub.4, NHCONH.sub.2, or OH;
• each R.sub.4 group is independently --COR.sub.5 where R.sub.5 is --OH, a pharmaceutically acceptable ester-forming group --OR.sub.6, or --OX where X is a pharmaceutically acceptable cation, or R.sub.5 is --N(R.sub.7).sub.2 where each R.sub.7 is independently H, or an aliphatic group of 1 to 10 carbon atoms, or a cycloalkyl-(CH.sub.2).sub.n - group of 4 to 10 carbons where n is 0-3, or both R.sub.7 groups form a ring having 4 to 6 carbons, or R.sub.4 is a sulfonamide, or tetrazol-5-yl;
• and
• R.sub.8 is hydrogen, C.sub.1 to C.sub.6 alkyl, or C.sub.1 to C.sub.6 -acyl,
• excluding those compounds where R.sub.2 and R.sub.3 are other than hydrogen and are substituted in the 2 and 6 positions.