US 5,633,250 AGranted

Imidazoylalkyl substituted with a six or seven membered heterocyclic ring containing two nitrogen atoms

AssigneeSchering Corporation

InventorNeng-Yang Shih

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Abstract

Disclosed us a compound of Formula 1.0: ##STR1## or a pharmaceutically acceptable salt or solvate thereof. Also disclosed are pharmaceutical compositions comprising a pharmaceutically acceptable carrier and an effective amount of a Compound of Formula 1.0. Further disclosed is a method of treating allergy (for example asthma), inflammation, hypertension, raised intraocular pressure (such as glaucoma)--i.e., a method of lowering intraocular pressure, sleeping disorders, states of hyper and hypo motility and acidic secretion of the gastrointestinal tract, hypo and hyperactivity of the central nervous system (for example, agitation and depression) and other CNS disorders (such as Alzheimers, Schizophrenia, and migraine) comprising administering an effective amount of a compound of Formula I to a patient in need of such treatment.

Claims9

Dependent claims

A compound of the formula:

##STR42## or a pharmaceutically acceptable salt or solvate thereof, wherein:
(A) n is 2, such that ring T is a seven membered ring;
(B) R.sup.1 is selected from the group consisting of:
(1) H;
(2) C.sub.1 to C.sub.6 alkyl;
(3) allyl;
and
(4) propargyl;
(C) R.sup.3 and R.sup.4 are independently selected from the group consisting of:
(1) H;
(2) C.sub.1 to C.sub.6 alkyl;
(3) allyl;
(4) propargyl;
and
(5) --(CH.sub.2).sub.q --R.sup.5 wherein q is an integer of:
1 to 7, and R.sup.5 is selected from the group consisting of:
phenyl, substituted phenyl, --OR.sup.6, --C(O)OR.sup.6, --C(O)R.sup.6, --OC(O)R.sup.6, --C(O)NR.sup.6 R.sup.7, CN and --SR.sup.6 wherein R.sup.6 and R.sup.7 are as defined below, and wherein the substituents on said substituted phenyl are each independently selected from the group consisting of:
--OH, --, O--(C.sub.1 to C.sub.6)alkyl, halogen, C.sub.1 to C.sub.6 alkyl, --CF.sub.3, --CN, and --NO.sub.2, and wherein said substituted phenyl contains from 1 to 3 substituents;
(D) R.sup.6 and R.sup.7 are each independently selected from the group consisting of:
H and C.sub.1 to C.sub.6 alkyl;
and
(E) R.sup.3 and R.sup.4 are each independently bound to the same or different carbon atom of ring T.

19 more elements

Dependencies are inferred from the claim text.