Amine compounds, their production and use

A gonadotropin-releasing hormone receptor antagonistic composition which comprises a compound of the formula:

• ##STR319## wherein Ar.sup.1 and Ar.sup.2 independently represent an optionally substituted aromatic group;
• P.sup.a and Q.sup.a independently represent a divalent aliphatic hydrocarbon group which may have either oxygen or sulfur within the carbon chain;
• R.sup.1a and R.sup.3a independently represent an acyl group or an optionally substituted hydrocarbon group;
• R.sup.2 and R.sup.4 independently represent hydrogen or an optionally substituted alkyl group;
• R.sup.1a and R.sup.2 or R.sup.3a and R.sup.4, taken together with the adjacent nitrogen atom, may form an optionally substituted nitrogen-containing heterocyclic group;
• and
• j represents 0 or 1, or a salt thereof, and
• a pharmaceutically acceptable carrier.

A method for treating diseases related to gonadotropin-releasing hormone in mammals which comprises the steps of selecting a compound of the formula:

• ##STR320## wherein Ar.sup.1 and Ar.sup.2 independently represent an optionally substituted aromatic group;
• P.sup.a and Q.sup.a independently represent a divalent aliphatic hydrocarbon group which may have either oxygen or sulfur within the carbon chain;
• R.sup.1a and R.sup.3a independently represent an acyl group or an optionally substituted hydrocarbon group;
• R.sup.2 and R.sup.4 independently represent hydrogen or an optionally substituted alkyl group;
• R.sup.1a and R.sup.2 or R.sup.3a and R.sup.4, taken together with the adjacent nitrogen atom, may form an optionally substituted nitrogen-containing heterocyclic group;
• and
• j represents 0 or 1, or a salt thereof, and administering to a subject a therapeutically effective amount of said compound.

A method of manufacturing a pharmaceutical composition for treating diseases related to gonadotropin-releasing hormone, comprising the steps of selecting a compound of the formula:

• ##STR321## wherein Ar.sup.1 and Ar.sup.2 independently represent an optionally substituted aromatic group;
• P.sup.a and Q.sup.a independently represent a divalent aliphatic hydrocarbon group which may have either oxygen or sulfur within the carbon chain;
• R.sup.1a and R.sup.3a independently represent an acyl group or an optionally substituted hydrocarbon group;
• R.sup.2 and R.sup.4 independently represent hydrogen or an optionally substituted alkyl group;
• R.sup.1a and R.sup.2 or R.sup.3a and R.sup.4, taken together with the adjacent nitrogen atom, may form an optionally substituted nitrogen-containing heterocyclic group;
• and
• j represents 0 or 1, or a salt thereof;
• and admixing said compound with a pharmaceutically acceptable carrier.