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US 5,633,247 AGranted
Nitrogen-containing spirocycles
AssigneeMerck & Co., Inc.
InventorsJohn J. Baldwin, David A. Claremon, Jason M. Elliott, Gerald S. Ponticello, David C. Remy, Harold G. Selnick
Life of this patent
Estimating the term…
Abstract
Spirocycles of general structural formula: ##STR1## are Class III antiarrhythmic agents.
Claims10
A compound of structural formula I:
- ##STR366## wherein:
- X and Y are independently --O--, CHOH, --(CH.sub.2)--;
- Z is --O--;
- M is ##STR367## R is C.sub.1-6 alkyl;
- R.sup.1, R.sup.2 and R.sup.3 are independently H, --NHSO.sub.2 (C.sub.1-6 alkyl), --CN;
- B is a ring of 5 to 8 members;
- and
- Ar is a single or fused ring carbocyclic or heterocyclic ring system containing up to 4 heteroatoms;
- or a pharmaceutically acceptable salt thereof.
6 more elements
A compound which is N-{1'-(6-cyano-1,2,3,4-tetrahydro-2-napthalenyl)-3,4-dihydo-4-hydroxyspiro [2H-1-benzopyran-2,4'-piperidinyl]methanesulfonamide, in the (R,R) form, the (R,S) form the (S,R) form, or the (S,S) form, or mixtures thereof, or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.