Parenteral solutions containing metolazone
AssigneeAcademic Pharmaceuticals, Inc.
InventorVasant Ranade
Life of this patent
Estimating the term…
Abstract
Disclosed herein are parenteral solutions containing 7-halo-1,2,3,4-tetrahydro-3-aryl-6-quinazoline sulfonamide in Tris or Bis-Tris or Tris buffer useful in the treatment of hypertension, heart disease and heart failure and renal disease. Also disclosed are methods for preparing such solutions.
Claims7
A solution suitable for parenteral administration comprising a compound of the formula ##STR2## dissolved in an aqueous Tris buffer system having a pH of from about 10.5 to 12.5.
A solution suitable for parenteral administration comprising metolazone dissolved in an aqueous Tris buffer system having a pH of from about 10.5 to 12.5.
A solution comprising an effective diuretic amount of a mixture of furosemide and metolazone in Tris buffer at a pH of from about 11.5 to 12.
Dependencies are inferred from the claim text.