Tachykinin antagonist dipeptides

A compound of the formula:

• ##STR142## wherein R.sup.1 is a group of the formula ##STR143## wherein the symbol of a line and a dotted line represent a single bond and X is CH.sub.2 or NH, or said line and dotted line represent a double bond and X is CH or N,
• Z is O, S or N--R.sup.6,
• wherein R.sup.6 is hydrogen, lower alkyl, or N,N-di(lower)alkylamino(lower)alkyl;
• R.sup.2 is hydrogen or lower alkyl;
• R.sup.3 is lower alkyl, carboxy(lower)alkyl, esterified carboxy(lower)alkyl, carbamoyl(lower)alkyl, lower alkylamino(lower)alkyl, hydroxy(lower)alkyl, acyloxy(lower)alkyl, halo(lower)alkyl, carboxy(lower)alkoxy, esterified carboxy(lower)alkoxy, halogen, lower alkoxy, nitro, amino, or an acylated amino group;
• R.sup.4 is lower alkyl, carboxy(lower)alkyl or esterified carboxy(lower)alkyl, and
• R.sup.5 is ar(lower)alkyl selected from the group consisting of mono-, di- and triphenyl(lower)alkyl or pyridyl(lower)alkyl, or ##STR144## represents a heterocyclic moiety selected from the group consisting of 1-indolinyl, 2-isoindolinyl, 1, 2, 3, 4-tetrahydroquinolin-1-yl and 1, 2, 3, 4-tetrahydroisoquinolin-2-yl;
• R.sup.7 is hydrogen, lower alkyl, carboxy(lower)alkyl, esterified carboxy(lower)alkyl, carbamoyl(lower)alkyl, lower alkylamino(lower)alkyl, hydroxy(lower)alkyl, acyloxy(lower)alkyl, halo(lower)alkyl carboxy(lower)alkoxy, esterified carboxy(lower)alkoxy, halogen, lower alkoxy, nitro, amino, or an acylated amino group;
• A represents an amino acid residue, wherein said amino acid is selected from the group consisting of D- or L-proline, D- or L-didehydroproline, D- or L-hydroxyproline, and D- or L-mercaptoproline,
• wherein if said amino acid is hydroxyproline or mercaptoproline, the amino acid side chain is optionally substituted with a moiety selected from the group consisting of lower alkanoyl, lower alkoxycarbonyl, trihalo(lower)alkoxy-carbonyl, C.sub.6 -C.sub.10 ar(lower)alkoxycarbonyl, lower alkylsulfonyl, lower alkoxyalyl, C.sub.6 -C.sub.10 arylsulfonyl, halo C.sub.6 -C.sub.10 ar(lower)-alkoxycarbonyl, carboxy(lower)alkanoyl, glycyl, .beta.-alanyl, N-lower alkoxycarbonylglycyl, N-lower alkoxycarbonyl-.beta.-alanyl, N,N-di(lower)alkylamino-(lower)alkanoyl, carboxyalyl, morpholino-carbonyl, amino(lower)alkanoyl, N-C.sub.6 -C.sub.10 ar(lower)alkoxycarbonyl-amino(lower)alkanoyl, threonyl, N-lower alkoxycarbonyl-threonyl, N-lower alkanoylthreonyl, N-lower alkoxycarbonyl(lower)alkyl-N-lower alkoxycarbonylamino-(lower)alkanoyl, .alpha.-glutamyl, N-C.sub.6 -C.sub.10 ar(lower)alkoxycarbonyl-O-C.sub.6 -C.sub.10 ar(lower)alkyl-.gamma.-glutamyl, lower alkyl, carboxy(lower)alkyl, esterified carboxy(lower)alkyl, morpholino, glycino amide, threonino amide, N'-glutamylamino, N-lower alkylamide, di(lower)alkylamino, C.sub.6 -C.sub.10 ar(lower)alkyl, trihalo(lower)alkyl and lower alkoxycarbonyl(lower)alkyl;
• and
• Y is a valence bond, lower alkylene or lower alkenylene;
• or a pharmaceutically acceptable salt thereof.