Convertible microemulsion formulations
AssigneeLDS Technologies, Inc.
InventorsAlbert J. Owen, Seang H. Yiv
Life of this patent
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Abstract
There is provided a water-in-oil (w/o) microemulsion which readily converts to an oil-in-water (o/w) emulsion by the addition of aqueous fluid to the w/o microemulsion, whereby any water-soluble biologically-active material in the aqueous phase is released for absorption by the body. The w/o microemulsion is particularly useful for storing proteins and the like for long periods of time at room temperature and above until they are ready for use, at which time the addition of aqueous fluid converts the microemulsion to an o/w emulsion and releases the protein.
Claims20
A biologically compatible water-in-oil microemulsion composition that converts to an oil-in-water emulsion by the addition of water, comprising:
- (a) up to about 60 volume percent of an internal dispersed aqueous phase comprising an effective amount of a biologically active material that is water soluble;
- (b) from about 5 to 99 volume percent of a continuous oil phase comprising at least one pharmaceutically-acceptable oil comprising a C.sub.9-83 triglyceride, a C.sub.7-55 diester of propylene glycol, or mixtures thereof;
- and
- (c) from about 1 to about 70 volume percent of a surfactant or surfactant mixture comprising a C.sub.8 fatty acid salt, wherein the surfactant or surfactant mixture has an HLB value of at least 7.
A biologically compatible water-in-oil microemulsion composition that converts to an oil-in-water emulsion by the addition of water, comprising:
- (a) up to about 20 volume percent of an internal dispersed aqueous phase comprising an effective amount of a biologically active material that is water soluble;
- (b) from about 30 to 99 volume percent of a continuous oil phase comprising at least one pharmaceutically-acceptable oil comprising a C.sub.9-83 triglyceride, a C.sub.7-55 diester of propylene glycol, or mixtures thereof;
- and
- (c) from about 1 to about 70 volume percent of a surfactant or surfactant mixture comprising a C.sub.8 fatty acid salt, wherein the surfactant or surfactant mixture has an HLB value of from 7 to 14.
A method of administering a biologically active material to an animal, comprising:
- (a) providing a biologically compatible water-in-oil microemulsion composition that converts to an oil-in-water emulsion by the addition of water, comprising:
- (1) up to about 20 volume percent of an internal dispersed aqueous phase comprising an effective amount of a therapeutic, biologically active material that is water soluble;
- (2) from about 30 to 99 volume percent of a continuous oil phase comprising at least one pharmaceutically-acceptable oil comprising a C.sub.9-83 triglyceride, a C.sub.7-55 diester of propylene glycol, or mixtures thereof;
- and
- (3) from about 1 to about 70 volume percent of a surfactant or surfactant mixture comprising a C.sub.8 fatty acid salt, wherein the surfactant or surfactant mixture has an HLB value of from 7 to 14;
- (b) administering said composition to an animal.
Dependencies are inferred from the claim text.