Method of controlling viral growth
AssigneeCarnegie Institution of Washington
InventorSteven L. McKnight
Life of this patent
Estimating the term…
Abstract
The present invention relates to a method of specifically inhibiting the growth of a virus, particularly an animal virus, in a permissive host cell comprising introducing into the host cell a virus-related gene encoding a product capable of interacting with the genome of the infecting virus (or a product encoded therein) in a manner such that the life cycle of the infecting virus is disrupted. The invention also relates to a method of rendering a cell, particularly an animal cell, resistant to viral infection, and to a viral resistant cell.
Claims3
A method of specifically inhibiting growth of a virus, that is a member of the family Herpesviridae, in a permissive mammalian host cell comprising:
- i) introducing into said cell a gene encoding a carboxyl-terminal truncated form of VP16 lacking activation function;
- and
- ii) causing expression of said gene and thereby production of said form of VP16 so that growth of said virus is inhibited.
A method of specifically inhibiting growth of a virus that is a member of the family Herpes viridae in a permissive mammalian host cell comprising:
- i) introducing into said cell a virus-related gene encoding a protein capable of specifically interacting with a product encoded in the genome of said virus so that the life cycle of said virus is disrupted;
- and
- ii) causing expression of said virus-related gene and interaction of said protein with said product encoded in the genome of said virus;
- said product encoded in the virus related gene is a trans-dominant form of a viral activator and said viral activator is a form of the HSV-specific activator VP16 lacking the activating domain.
Dependencies are inferred from the claim text.