Transforming growth factor .alpha.H1
AssigneeHuman Genome Sciences, Inc.
InventorsPaul S. Meissner, Rebecca A. Fuldner, Mark D. Adams
Life of this patent
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Abstract
Disclosed is a human TGF.alpha.-H1 polypeptide and DNA (RNA) encoding such TGF.alpha.-H1 polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques and for producing antibodies and antagonists against such polypeptide. Such polypeptides may be combined with a suitable pharmaceutical carrier or diluent to provide diagnostic, therapeutic and/or prophylactic effects against various diseases. Also provided, are methods of using the antibodies and antagonists to inhibit TGF.alpha.-H1 for therapeutic purposes.
Claims36
An isolated polynucleotide comprising a polynucleotide having at least a 95% identity to a member selected from the group consisting of:
- (a) a polynucleotide encoding a polypeptide comprising the amino acid sequence as set forth in SEQ ID NO:2;
- and
- (b) a polynucleotide which is complementary to the polynucleotide of (a).
An isolated polynucleotide comprising a polynucleotide having at least a 95% identity to a member selected from the group consisting of:
- (a) a polynucleotide encoding a polypeptide comprising amino acid 19 to amino acid 68 as set forth in SEQ ID NO:2;
- and
- (b) a polynucleotide which is complementary to the polynucleotide of (a).
An isolated polynucleotide comprising nucleotide 7 to nucleotide 3282 of SEQ ID NO:3.
An isolated polynucleotide comprising a polynucleotide having at least a 95% identity to a member selected from the group consisting of:
- (a) a polynucleotide encoding the polypeptide encoded by the human Transforming Growth Factor -.alpha.H1 (TGF.alpha.-H1) cDNA contained in ATCC Deposit No. 75698;
- and
- (b) a polynucleotide which is complementary to the polynucleotide of (a).
An isolated polynucleotide comprising a polynucleotide having at least a 95% identity to a member selected from the group consisting of:
- (a) a polynucleotide encoding the soluble polypeptide variant of TGF.alpha.-H1, wherein said variant lacks the transmembrane portion of TGF.alpha.-H1, and is encoded by the human TGF.alpha.-H1 cDNA contained in ATCC Deposit No. 75698;
- and
- (b) a polynucleotide which is complementary to the polynucleotide of (a).
Dependencies are inferred from the claim text.