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US 5,633,142 AGranted
WT1 monoclonal antibodies and methods of use therefor
AssigneeThe Wistar Institute of Anatomy and Biology
InventorsMeenhard Herlyn, Jennifer Morris, Frank J. Rauscher, III, Ulrich Rodeck
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Abstract
The present invention provides three unique monoclonal antibodies directed against a portion of the Wilms' tumor antigen, and methods of use therefor in detecting, monitoring and diagnosing malignancies characterized by over-expression or inappropriate expression of the WT 1 protein.
Claims4
A method for diagnosing a disease condition characterized by WT1 expression comprising the steps of:
- a) providing a biological sample from a patient having the clinical symptoms associated with mesothelioma;
- b) providing a monoclonal antibody selected from the group consisting of H2 which is secreted by hybridoma cell line ATCC No. 11598, H7 which is secreted by hybridoma cell line ATCC No. 11599, HC17 which is secreted by hybridoma cell line ATCC No. 11600, and a cocktail of any combination of the H2, H7 and HC17 antibodies;
- c) contacting said sample with said monoclonal antibody;
- and
- d) detecting the presence of binding of said monoclonal antibody to said biological sample, wherein the presence of such binding indicates the presence of said disease condition.
2 more elements
A method of monitoring therapy in leukemia patients comprising the steps of:
- a) providing a biological sample from a patient treated for leukemia;
- b) providing a monoclonal antibody selected from the group consisting of H2 which is secreted by hybridoma cell line ATCC No. 11598, H7 which is secreted bY hybridoma cell line ATCC No. 11599, HC17 which is secreted by hybridoma cell line ATCC No. 11600, and a cocktail of any combination of the H2, H7 and HC17 antibodies;
- c) contacting said sample with said monoclonal antibody;
- and
- d) detecting the presence of binding of said monoclonal antibody to said biological sample, wherein the presence of such binding indicates the presence of active leukemia cells.
2 more elements
Dependencies are inferred from the claim text.