Injectable pharmaceutical composition
AssigneeAplicaciones Farmaceuticas S.A. de C.V.
InventorsJosue Garza Flores, Laura P. Laiseca Soto, Jose Guillen Pichardo, Juan Angeles Uribe
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Abstract
Formulations of programmed-release medicinal products intended for parenteral administration by injection, comprising calibrated solid microspheres (1 to 300 microns) of active substances. Provided in this form, steroids (for example progesterone and 17-.beta.-estradiol) may constitute injectable contraceptives, and the action of drugs having an approximatively 24 hours lasting effect may be regulated and extended.
Claims1
Solid, non-porous microspheres for administration to a receiving organism said microspheres having a diameter in the range of 1-300 .mu.m, and consisting essentially of:
- an injectable analgesic that undergoes a decomposition reaction below the melting temperature of said analgesic;
- and
- an adjuvant not active on the receiving organism but which, when mixed with the analgesic, decreases the melting point of the analgesic below its decomposition temperature
- and wherein said microspheres are obtained by spraying a mixture of said analgesic and adjuvant in the melted state to form droplets and rapidly freezing said droplets.
Dependencies are inferred from the claim text.