Transdermal administration of azapirones
AssigneeSano Corporation
InventorsJames N. Kenealy, Cheryl M. Gentile
Life of this patent
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Abstract
In accordance with the present invention, a method and device is provided for administering therapeutically effective doses of the drug azospirone transdermally for treating psychogenic symptomatologies. One embodiment of the present invention comprises an effective amount of solubilized azospirone in a transdermal drug delivery device. By practicing the present invention, constant blood concentrations of azospirone can be maintained over a prolonged period of time, side effects can be minimized with maximal patient compliance.
Claims16
A method of administering a therapeutically effective amount of buspirone to a warm-blooded animal in need of such administration, comprising applying to the skin of the warm-blooded animal a composition comprising:
- a. a polyisobutylene pressure-sensitive adhesive layer containing the buspirone and an amount of isocetyl alcohol effective to inhibit recrystallization of the buspirone within the polyisobutylene pressure-sensitive adhesive layer, the polyisobutylene pressure-sensitive adhesive layer having a first face and a second face;
- and
- b. a backing layer substantially impermeable to the buspirone and contacting the first face of the polyisobutylene pressure-sensitive adhesive layer.
A method of administering a therapeutically effective amount of buspirone to a warm-blooded animal in need of such administration, comprising applying to the skin of the warm-blooded animal a composition comprising:
- a. a pressure-sensitive adhesive layer containing the buspirone and a solubilizing agent effective to inhibit recrystallization of the buspirone within the pressure-sensitive adhesive layer, the pressure-sensitive adhesive layer having a first face and a second face;
- and
- b. a backing layer impermeable to the buspirone mid contacting the first face of the pressure-sensitive adhesive layer.
A transdermal drug delivery device, comprising:
- a. a polyisobutylene adhesive layer containing buspirone and an amount of isocetyl alcohol effective to inhibit recrystallization of the buspirone within the polyisobutylene adhesive layer, the polyisobutylene adhesive layer having a first face and a second face, and
- b. a backing layer substantially impermeable to the buspirone and contacting the first face of the polyisobutylene adhesive layer.
A transdermal drug delivery device, comprising:
- a. a pressure-sensitive adhesive layer containing buspirone and an amount of a solubilizing agent effective to inhibit recrystallization of the buspirone within the pressure-sensitive adhesive layer, the pressure-sensitive adhesive layer having a first face and a second face, and
- b. a backing layer substantially impermeable to the buspirone and contacting the first face of the pressure-sensitive adhesive layer.
Dependencies are inferred from the claim text.