Granular agent for ruminants and process for producing the same

A process for producing a granular agent for ruminants comprising a core granular agent containing a physiologically active substance and a coating layer, which comprises providing a core granular agent containing said physiologically active substance, and coating said core granular agent in a form in which said core granular agent is covered by a coating layer comprising:

• (a) a first coating material composed of one or more substances selected from the group consisting of a fatty acid having 12 to 22 carbon atoms or ester thereof, an animal or vegetable fat and fatty oil or a hardened animal or vegetable fat and fatty oil, having a melting point of 40.degree. C. or higher, and a wax having a melting point of 40.degree. C. or higher, and
• (b) a second coating material composed of tabular crystals of a substance which is sparingly water-soluble under a neutral condition but is readily water-soluble under an acidic condition and which has an average particle size of 5 to 30 .mu.m,
• wherein said substance which is sparingly water-soluble under a neutral condition but readily Water-soluble under an acidic condition is at least one substance selected from the group consisting of isoleucine, L-cystine, methionine and secondary calcium phosphate dihydrate,
• wherein said coating layer has a laminar structure in which said tabular crystals are arranged in a laminated state,
• wherein said first coating material and said second coating material are in a proportion of 3:2 to 1:3 by weight, and
• wherein said coating layer is present in a coating ratio of 5% by weight or more and 50% by weight or less, based on the total weight of the granular agent.

A granular agent for ruminants comprising a core granular agent containing a physiologically active substance coated with a coating layer comprising

• (a) a first coating material composed of one or more substances selected from the group consisting of a fatty acid having 12 to 22 carbon atoms or ester thereof, an animal or vegetable fat and fatty oil or a hardened animal or vegetable fat and fatty oil, having a melting point of 40.degree. C. or higher, and a wax having a melting point of 40.degree. C. or higher, and
• (b) a second coating material composed of tabular crystals of a substance which is sparingly water-soluble under a neutral condition but is readily water-soluble under an acidic condition and which has an average particle size of 5 to 30 .mu.m,
• wherein said substance which is sparingly water-soluble under a neutral condition but readily water-soluble under an acidic condition is at least one substance selected from the group consisting of isoleucine, L-cystine, methionine and secondary calcium phosphate dihydrate,
• wherein the dissolution rate of a physiologically active substance of said granular agent is not higher than 50% when measured under the condition consisting of pH 7.1, 39.degree. C. and 18 hours, and the dissolution rate of said substance of said granular agent is not lower than 20% when measured under the condition consisting of pH 2, 39.degree. C. and 18 hours.

A process for producing a granular agent for ruminants comprising a core granular agent containing a physiologically active substance coated with a coating layer comprising

• (a) a first coating material composed of one or more substances selected from the group consisting of a fatty acid having 12 to 22 carbon atoms or ester thereof, an animal or vegetable fat and fatty oil or a hardened animal or vegetable fat and fatty oil, having a melting point of 40.degree. C. or higher, and a wax having a melting point of 40.degree. C. or higher, and
• (b) a second coating material composed of tabular crystals of a substance which is sparingly water-soluble under a neutral condition but is readily water-soluble under an acidic condition and which has an average particle size of 5 to 30 .mu.m,
• wherein said substance which is sparingly water-soluble under a neutral condition but readily water-soluble under an acidic condition is at least one substance selected from the group consisting of isoleucine, L-cystine, methionine and secondary calcium phosphate dihydrate,
• wherein the dissolution rate of a physiologically active substance of said granular agent is not higher than 50% when measured under the condition consisting of pH 7.1, 39.degree. C. and 18 hours, and the dissolution rate of said substance of said granular agent is not lower than 20% when measured under the condition consisting of pH 2, 39.degree. C. and 18 hours.