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US 5,632,991 AGranted
Antibodies specific for E-selectin and the uses thereof
AssigneeThe Brigham and Women's Hospital, Inc.
InventorMichael A. Gimbrone, Jr.
Life of this patent
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AssigneeThe Brigham and Women's Hospital, Inc.
InventorMichael A. Gimbrone, Jr.
Estimating the term…
A method is provided for selectively targeting a therapeutic agent to a site of activated endothelium by administering a pharmaceutical composition comprising a therapeutically effective amount of an E-selectin (formerly called ELAM-1) specific monoclonal antibody conjugated to a therapeutic agent. An immunoconjugate comprising an E-selectin specific monoclonal antibody and a therapeutic agent is also provided. A method is also provided for the treatment of a vascular smooth muscle cell proliferative disorder, vasculitis, inflammation, post-reperfusion injury, microbial infections, acute or chronic allograft rejection, and leukemia, as well as for the inhibition of metastatic spread of tumor cells, by administering a pharmaceutical composition comprising a therapeutically effective amount of an E-selectin antibody, or antibody fragment, either alone, or conjugated to a therapeutic agent.
A method for selectively targeting a therapeutic agent to activated endothelium expressing E-selectin, comprising administering to a patient a pharmaceutical composition comprising a therapeutically effective amount of an immunoconjugate comprising monoclonal antibody H18/7, or a fragment of said antibody which binds to E-selectin, conjugated to a therapeutic agent, and a pharmaceutically acceptable carrier.
An immunoconjugate comprising a monoclonal antibody H18/7, or a fragment of said antibody which binds to E-selectin, conjugated to a therapeutic agent.
A method for the treatment of inflammation, comprising administering to a patient a pharmaceutical composition comprising a therapeutically effective amount of an immunoconjugate comprising monoclonal antibody H18/7, or a fragment of said antibody which binds to E-selectin, conjugated to an anti-inflammatory agent, and a pharmaceutically acceptable carrier.
A method for the treatment of a microbial infection, comprising administering to a patient a pharmaceutical composition comprising a therapeutically effective amount of an immunoconjugate comprising monoclonal antibody H18/7, or a fragment of said antibody which binds to E-selectin, conjugated to an anti-microbial agent, and a pharmaceutically acceptable carrier.
A method for the treatment of post-reperfusion injury, comprising administering to a patient a pharmaceutical composition comprising a therapeutically effective amount of an immunoconjugate comprising monoclonal antibody H18/7, or a fragment of said antibody which binds to E-selectin, conjugated to an anti-thrombotic agent, antioxidant, anti-complement agent, or anti-inflammatory agent, and a pharmaceutically acceptable carrier.
A method for the treatment of a malignant tumor, comprising administering to a patient a pharmaceutical composition comprising a therapeutically effective amount of an immunoconjugate comprising monoclonal antibody H18/7, or a fragment of said antibody which binds to E-selectin, conjugated to an anti-tumor agent, and a pharmaceutically acceptable carrier.
A method for the treatment of vasculitis, comprising administering to a patient a pharmaceutical composition comprising a therapeutically effective amount of an immunoconjugate comprising monoclonal antibody H18/7, or a fragment of said antibody which binds to E-selectin, conjugated to an anti-inflammatory agent, anti-thrombotic agent, anti-thrombolytic agent, or anti-complement agent, and a pharmaceutically acceptable carrier.
A method for the treatment of a vascular smooth muscle cell proliferative disorder, comprising administering to a patient a pharmaceutical composition comprising a therapeutically effective amount of an immunoconjugate comprising monoclonal antibody H18/7, or a fragment of said antibody which binds to E-selectin, conjugated to an anti-smooth muscle cell proliferative agent, and a pharmaceutically acceptable carrier.
A method for the treatment of acute or chronic allograft rejection, comprising administering to a patient a pharmaceutical composition comprising a therapeutically effective amount of an immunoconjugate comprising monoclonal antibody H18/7, or a fragment of said antibody which binds to E-selectin, conjugated to an anti-inflammatory agent, anti-thrombotic agent, anti-complement agent, or immunosuppressive agent, and a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.