Attenuated, live vaccine for Delaware strain IBDV
AssigneeUniversity of Maryland
InventorsDavid B. Snyder, Vikram Vakharia, Heinrich D. Luetticken
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Abstract
Live, attenuated Delaware infectious bursal disease viruses are screened for effectiveness by a monoclonal antibody specific for said Delaware strain. Those which are not bound by the antibody are not or may not be as effective in conferring protection against homologous wild type infectious bursal disease infection. Currently available live, attenuated vaccines do not include a virus having the binding site specified. A monoclonal antibody specific for the Delaware strain also provides a vaccine for passive immunization.
Claims8
A live, attenuated infectious bursal disease virus (IBDV) capable of inducing antibodies to wild-type Delaware IBDV in poultry when administered thereto, but sufficiently attenuated so as not to induce infectious bursal disease in said treated poultry, said live, attenuated virus bearing a BK9 monoclonal antibody marker.
A monoclonal antibody which neutralizes wild-type Delaware IBDV, designated Mab 67.
Dependencies are inferred from the claim text.