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US 5,632,986 AGranted
Phospholipid-targeted thrombolytic agents
AssigneeUniversity of Washington
InventorsJonathan F. Tait, Kazuo Fujikawa
Life of this patent
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Abstract
Conjugates with an affinity for phospholipids are disclosed. The conjugates comprise a first compound having affinity for phospholipids, with a binding constant that is not greater than about 10.sup.-7 M and a second compound that lyses thrombi or is a precursor of a compound that lyses thrombi.
Claims3
A conjugate comprising:
- (a) an annexin covalently linked to
- (b) urokinase.
A therapeutic composition comprising in an amount effective to lyse thrombi, a conjugate of
- (a) an annexin covalently linked to
- (b) urokinase;
- (c)and a said composition contains a pharmaceutically acceptable carrier, diluent or excipient.
A method of lysing thrombi comprising administering to a host in need of treatment a therapeutically effective amount of a composition comprising:
- (1) a conjugate comprising:
- (a) an annexin covalently linked to
- (b) urokinase;
- and
- (2) a pharmaceutically acceptable carrier, diluent or excipient.
2 more elements
Dependencies are inferred from the claim text.