Method of treatment of macular degeneration
AssigneeOculex Pharmaceuticals, Inc.
InventorsVernon G. Wong, King Y. Lee, Jerry B. Gin
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Abstract
Intraocular administration of drugs such as .alpha.-2a interferon is employed in the treatment of age-related macular degeneration. Intraocular administration obviates the side effects associated with systemic administration, concentrates the drug at the site of the disease, and, where microcapsules are employed, provides continuous, long-lasting treatment.
Claims9
A method of treatment of macular degeneration associated with subretinal neovascularization in a mammalian host, said method comprising the steps of:
- administering intraocularly interferon to said host in an amount sufficient to elicit a decrease in hemorrhage or leakage associated with said subretinal neovascularization wherein said administering is by at least 3 injections at intervals from about three to 42 days.
A method of treatment of macular degeneration associated with subretinal neovascularization in a human host, said method comprising the steps of:
- injecting intraocularly at least three injections at intervals of from about three to forty-two days of .alpha.-2a interferon to said human host in an amount ranging from at least about 10,000 to 100,000 units, said amount being sufficient to elicit a decrease in hemorrhage or leakage associated with said subretinal neovascularization.
A method of treatment of macular degeneration associated with subretinal neovascularization in a human host, said method comprising the steps of:
- administering intraocularly interferon contained within biodegradable microcapsules to said host in an amount sufficient to maintain an intraocular concentration over a period of from about two weeks to 14 months so as to elicit a decrease in hemorrhage or leakage associated with said subretinal neovascularization.
Dependencies are inferred from the claim text.