Biopolymer-bound nitric oxide-releasing compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same
AssigneeThe United States of America as represented by the Department of Health and Human Services
InventorsJoseph E. Saavedra, Larry K. Keefer, Peter P. Roller, Miki Akamatsu
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Abstract
A polymeric composition capable of releasing nitric oxide under physiological conditions which includes a biopolymer, such as a peptide, polypeptide, protein, oligonucleotide or nucleic acid, to which is bound a nitric oxide-releasing N.sub.2 O.sub.2.sup.- functional group; pharmaceutical compositions comprising the polymeric composition; and methods of treating biological disorders in which dosage with nitric oxide is therapeutic.
Claims28
A polymeric composition capable of releasing nitric oxide, said composition comprising a biopolymeric backbone wherein said backbone is of a protein, and at least one nitric oxide-releasing N.sub.2 O.sub.2.sup.- function group selected from the group consisting of X--N(O)NO] or [N(O)NO--X, wherein X is an organic moiety, covalently bonded to said [N.sub.2 O.sub.2 ], and wherein the [N.sub.2 O.sub.2 ] group is covalently bonded in said polymeric composition through said organic moiety X.
Dependencies are inferred from the claim text.