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US 5,632,980 AGranted
AIDS therapeutic agents comprising polymers formed from cinnamic acid derivatives
OwnerKunio Konno, Hiroshi Sakagami +2inventors
InventorsKunio Konno, Hiroshi Sakagami, Yutaka Kawazoe, Naoki Yamamoto
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Abstract
AIDS therapeutic agents are provided which are less toxic, have a strong anti-AIDS virus activity and comprise as an effective ingredient a dehydrogenation polymer of a cinnamic acid derivative having a phenyl group substituted with at least one hydroxyl group or a pharmaceutically acceptable salt thereof.
Claims35
An AIDS therapeutic agent comprising:
- a pharmaceutically effective amount of a polymer shown to be effective against HIV-1 and 2 viruses in MT-4 cell tests obtained by polymerizing in the presence of hydrogen peroxide and peroxidase or its pharmaceutically acceptable salt a cinnamic acid derivative represented by the formula:
- R--CH.dbd.CH--COOH
- where R is a phenyl substituted with at least one hydroxyl group;
- and
- a pharmaceutically effective carrier.
2 more elements
A composition comprising:
- a polymer shown to be effective against HIV-1 and viruses in MT-4 cell tests obtained by polymerizing in the presence of hydrogen peroxide and peroxidase or its pharmaceutically acceptable salt a cinnamic acid derivative represented by the formula:
- ##STR1## where R is independently H, OH or OCH.sub.3 with the proviso that at least one R is OH;
- and
- pharmaceutically effective carrier.
1 more element
Dependencies are inferred from the claim text.