Method and composition for preventing surgical adhesions
AssigneeUniversity of Florida Research Foundation, Inc.
InventorsEugene P. Goldberg, Yoseph Yaacobi
Life of this patent
Estimating the term…
Abstract
An improved method and composition for preventing adhesions during surgery. Tissue surfaces and surgical articles involved in the surgery are coated with a solution of a hydrophilic, polymeric material prior to manipulation of the tissue during surgery. The composition comprises a solution of a polymeric material having a molecular weight of about 500,000 or above having a concentration of from about 0.01 to about 15%, by weight.
Claims4
In a method of preventing surgical adhesions of tissue in surgery comprising coating surfaces involved in said surgery with an aqueous solution of a hydrophilic, polymeric material prior to manipulation of tissue involved in said surgery wherein said polymeric material is a member selected from the group consisting of water-soluble, biocompatible, pharmaceutically acceptable, non-toxic, non-immunogenic polypeptides, salts and complexes thereof and mixtures thereof, the improvement wherein said hydrophilic, polymeric material (1) has a molecular weight of about 500,000 or above, and (2) has a concentration in said aqueous solution in the range of from about 0.01% to about 15%, by weight.
In a method of preventing surgical adhesions of tissue in surgery comprising coating the surfaces of tissue involved in said surgery with an aqueous solution of a hydrophilic, polymeric material prior to manipulation of said tissue during said surgery wherein said polymeric material is a member selected from the group consisting of water-soluble, biocompatible, pharmaceutically acceptable, non-toxic, non-immunogenic polypeptides, salts and complexes thereof and mixtures thereof, the improvement wherein said hydrophilic, polymeric material (1) has a molecular weight of about 500,000 or above, and (2) has a concentration in said aqueous solution in the range of from about 0.01% to about 15%, by weight.
In a method of preventing surgical adhesions of tissue in surgery comprising coating the surfaces of surgical articles which contact tissue surfaces involved in said surgery with an aqueous solution of a hydrophilic, polymeric material prior to manipulation of said tissue during said surgery wherein said polymeric material is a member selected from the group consisting of water-soluble, biocompatible, pharmaceutically acceptable, non-toxic, non-immunogenic polypeptides, salts and complexes thereof and mixtures thereof, the improvement wherein said hydrophilic, polymeric material (1) has a molecular weight of about 500,000 or above, and (2) has a concentration in said aqueous solution in the range of from about 0.01% to about 15%, by weight.
Dependencies are inferred from the claim text.