Detection of cardiovascular lesions
AssigneeImmunomedics, Inc.
InventorDavid M. Goldenberg
Life of this patent
Estimating the term…
Abstract
This invention relates to reagents and methods for detecting and imaging cardiovascular lesions such as atherosclerotic plaques, vascular clots including thrombi and emboli, myocardial infarction, and other organ infarcts. Monospecific antibody imaging agent conjugates specific for one type of leukocyte, as well as multispecific antibody imaging agent conjugates specific for at least one type of leukocyte and for antigens associated with fibrin, myosin or platelets, are used in the present invention. Multispecific antibody imaging agent conjugates specific for at least two different antigens selected from the group consisting of fibrin-, myosin- and platelet associated antigens are also provided.
Claims8
A method for detecting and imaging atherosclerotic plaque in the absence of inflammation, which comprises insecting a mammal intravenously or intraarterially with an effective amount for detecting and imaging of a monospecific conjugate comprising an imaging agent conjugated to an antibody or antibody fragment which binds specifically to a monocyte, and obtaining an image of atherosclerotic plaque after sufficient time for said conjugate to bind to said plaque and for unbound conjugate to clear.
Dependencies are inferred from the claim text.