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US 5,632,898 AGranted
Method for removing unreacted electrophiles from a reaction mixture
AssigneeIsis Pharmaceuticals, Inc.
InventorsMichael E. Jung, Phillip D. Cook, Andrew M. Kawasaki
Life of this patent
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Abstract
Simple and efficient methods for scavenging excess electrophiles from a reaction mixture are provided utilizing addition of water soluble nucleophiles or solid support bound nucleophiles. Resulting addition products are removed from reaction mixtures through convenient separation techniques.
Claims14
A method for scavenging an electrophile from a reaction mixture comprising:
- adding to said reaction mixture a compound having the formula:
- Q--R.sub.1 --Z(O).sub.n O--M.sub.1
- wherein
- n is 1, 2 or 3;
- Q is a nucleophile;
- Z is C, P or S;
- M.sub.1 is hydrogen or a metal ion selected such that said compound is water soluble at room temperature;
- and
- R.sub.1 is C.sub.1 -C.sub.10 hydrocarbyl;
- in an amount sufficient to react with said electrophile in said reaction mixture to form an addition compound;
- and
- separating said addition compound from the reaction mixture.
9 more elements
Dependencies are inferred from the claim text.