Implantation materials
AssigneeToray Industries, Inc.
InventorsHajimu Kurumatani, Hiroshi Kataoka, Kyoko Yamada
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Abstract
The present invention is implantation materials comprising an anti-thrombogenic material contained in the surface in contact with blood, of a porous substrate with its voids filled with denatured albumin or a biodegradable polyester. Since they are excellent in anti-thrombogenic property and allow the positive introduction of cells into the implantation materials, they can prevent thrombogenesis for long periods of time. Especially even if they are used as artificial small diameter blood vessels of less than 6 mm in inner diameter, they show excellent patency.
Claims15
An anti-thrombogenic implantation material consisting essentially of a layer of a porous substrate made of individual fibers having voids filled with a biodegradable polymer and a layer of an anti-thrombogenic agent formed onto a surface portion formed by said substrate and said biodegradable polymer, wherein said porous substrate has a coefficient of water permeability of 500 to 5,000 ml/cm.sup.2 /min. 120 mmHg and said biodegradable polymer has a degradation period that is shorter than that of said anti-thrombogenic agent of said layer.
Dependencies are inferred from the claim text.