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AssigneeThe Trustees of Columbia University in the City of New York
InventorsVincent Racaniello, Cathy Mendelsohn, Frank Costantini
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The subject invention provides an isolated nucleic acid molecule which comprises nucleic acid encoding a polypeptide which has the biological activity of a receptor for poliovirus and in addition, provides a purified polypeptide which has this activity. The subject invention also provides a method for inducing the production of a polypeptides which includes the use of expression vectors in a host vector system. Therapeutic compositions comprising purified polypeptides which have the biological activity of a receptor for poliovirus are also provided for as are methods of treating and preventing human poliovirus infection. Further, the subject invention provides a method of producing a transgenic animal expressing human poliovirus receptors. The subject invention provides a method of testing the efficacy of a poliovirus receptors vaccine which comprises administering the vaccine to a transgenic animal described above and determining whether the resulting transgenic animal is protected from infection by human picornavirus. Lastly, a method of testing the virulence of a picornavirus vaccine is provided.
A transgenic mouse which has stably integrated into the genome of its somatic and germ cells the DNA sequence H20A of FIG. 4 which encodes a human poliovirus receptor, wherein expression of said DNA sequence results in the mice becoming susceptible to poliovirus infection.
A transgenic mouse which has stably integrated into the genome of its somatic and germ cells the DNA sequence H20B of FIG. 4 which encodes a human poliovirus receptor, wherein expression of said DNA sequence results in the mice becoming susceptible to poliovirus infection.
A method of producing a transgenic mouse which expresses a human poliovirus receptor comprising:
A method of producing a transgenic mouse which expresses a human poliovirus receptor comprising:
Dependencies are inferred from the claim text.