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US 5,631,383 AGranted
Derivatives of 2-azabicyclo[2.2.1]heptane, their preparation and their application
AssigneeRhone-Poulenc Rorer S.A.
InventorsDenis Largeau, Patrick Leon
Life of this patent
Estimating the term…
Abstract
Novel derivatives of 1R- or 1S-2-azabicyclo[2.2.1]heptane with the general formula (I) or (I'), their preparation and their application; ##STR1##
Claims6
A 1R- or 1S 2-azabicyclo [2.2.1]heptane compound of formula:
- ##STR12## wherein R represents a hydrogen atom or, respectively, a group with the formula:
- ##STR13## wherein R.sub.1 represents an alkyl group containing 1-4 carbon atoms and Ar represents a phenyl or .alpha.- or .beta.-naphthyl group, optionally substituted by one or more atoms or groups, which are identical or different, selected from halogen atoms, alkyl groups containing 1-4 carbon atoms, alkoxy groups containing 1-4 carbon atoms or a nitro group.
A compound of formula:
- ##STR14## wherein R'.sub.1 and R".sub.1, which are identical or different, represent an acyl group of an aliphatic organic acid containing 2-4 carbon atoms, or an aroyl group of an aromatic acid or R'.sub.1 and R".sub.1 taken together form a methylene group whose carbon atom is optionally substituted by one or two groups, which are identical or different, selected from phenyl groups or alkyl groups containing 1 to 4 carbon atoms, or the alkyl groups taken together form an alicyclic group containing 5 or 6 carbon atoms, and G.sub.2 represents a hydrogen atom or a protecting group for the nitrogen atom of the amido group of the compound.
A compound of formula:
- ##STR15## wherein R represents a h,ydrogen atom or a group with the general formula (II) as defined in claim 11 and R'.sub.1 and R".sub.1, which are identical or different, represent an acyl group of an aliphatic organic acid containing 2-4 carbon atoms, or an aroyl group of an aromatic acid or R'.sub.1 and R".sub.1 taken together form a methylene group whose carbon atom is optionally substituted by one or two groups, which are identical or different, selected from phenyl groups or alkyl groups containing 1 to 4 carbon atoms, or the alkyl groups taken together form an alicyclic group containing 5 or 6 carbon atoms.
A compound of formula:
- ##STR16## wherein R'.sub.1 and R".sub.1, which may be identical or different, represent an acyl group of an aliphatic organic acid containing 2-4 carbon atoms, or an aroyl group of an aromatic acid or R'.sub.1 and R".sub.1 taken together form a methylene group whose carbon atom is optionally substituted by one or two groups, which are identical or different, selected from phenyl groups or alkyl groups containing 1 to 4 carbon atoms, or the alkyl groups taken together form an alicyclic group containing 5 or 6 carbon atoms, and G.sub.2 represents a protecting group for the nitrogen atom of the amido group of the compound.
Dependencies are inferred from the claim text.