Process for piperidine derivatives
AssigneeMerrell Pharmaceuticals Inc.
InventorsChi-Hsin R. King, Michele A. Kaminski, Teng-Man Chen
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Abstract
The present invention is related to a novel process for preparing certain piperidine derivatives which are useful as antihistamines, antiallergy agents and bronchodilators, these piperidine derivatives can be described by the following formulas: ##STR1## wherein R.sub.1 represents hydrogen or hydroxy; R.sub.2 represents hydrogen; or R.sub.1 and R.sub.2 taken together form a second bond between the carbon atoms bearing R.sub.1 and R.sub.2 ; n is an integer of from 1 to 5; R.sub.3 is --CH.sub.2 OH, --COOH or --COOalkyl wherein the alkyl moiety has from 1 to 6 carbon atoms and is straight or branched; each of A is hydrogen or hydroxy; and pharmaceutically acceptable salts, hydrates and individual optical isomers thereof.
Claims2
A compound of the formula ##STR9## wherein R.sub.1 represents hydrogen or hydroxy;
- R.sub.2 represents hydrogen;
- or
- R.sub.1 and R.sub.2 taken together form a second bond between the carbon atoms bearing R.sub.1 and R.sub.2 ;
- A is hydrogen or hydroxy;
- n is an integer of from 1 to 5;
- and
- pharmaceutically acceptable salts, hydrates and individual optical isomers thereof.
A compound of the formula ##STR10## wherein R.sub.1 represents hydrogen or hydroxy;
- R.sub.2 represents hydrogen;
- or
- R.sub.1 and R.sub.2 taken together form a second bond between the carbon atoms bearing R.sub.1 and R.sub.2 ;
- A is hydrogen or hydroxy;
- n is an integer of from 1 to 5;
- and
- pharmaceutically acceptable salts, hydrates and individual optical isomers thereof.
Dependencies are inferred from the claim text.