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US 5,631,363 AGranted
Azetidinone compound and process for preparation thereof
AssigneeTanabe Seiyaku Co., Ltd.
InventorsTameo Iwasaki, Kazuhiko Kondo
Life of this patent
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Abstract
There is disclosed an azetidinone compound of the formula [I]: ##STR1## wherein Ring B is a benzene ring which may have substituent(s), R.sup.1 is a hydroxy-substituted lower alkyl group which may have substituent(s), X is oxygen atom and the like, Y is oxygen atom and the like, and Z is a methylene group which may have substituent(s), which is useful as a synthetic intermediate of the 1.beta.-methylcarbapenem-type antibacterial agent.
Claims5
An .alpha.-halopropionamide compound of the formula [II]:
- ##STR78## wherein Ring B is a benzene ring which may be substituted by one to four group(s) selected from the group consisting of a halogen atom, a lower alkyl group, a lower alkoxy group and an aryl group, X is an oxygen atom or a sulfur atom, Y is an oxygen atom, a sulfur atom, a methylene group or an imino group which may be substituted by a lower alkyl group, an acyl group or an aralkyloxycarbonyl group, Z is a methylene group which may be substituted by one to two group(s) selected from the group consisting of a C.sub.3-7 alkylene group, a C.sub.1-20 alkyl group, a C.sub.4-7 cycloalkyl group (said alkylene group, alkyl group and cycloalkyl group being further optionally substituted), an aryl group, an aralkyl group and a heterocyclic group, and L.sup.0 is a halogen atom, or a salt thereof.
3-(2-Bromoprop ionyl)-spiro[2,3-dihydro-4H-1,3-benzoxazine-2,1'-cyclohexan]-4-one.
Dependencies are inferred from the claim text.