Hairpin ribozymes
AssigneeRibozyme Pharmaceuticals, Inc.
InventorsBharat Chowrira, James McSwiggen
Life of this patent
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Abstract
Hairpin ribozyme lacking a substrate moiety, comprising at least six bases in helix 2 and able to base-pair with a separate substrate RNA, wherein the ribozyme comprises one or more bases 3' of helix 3 able to base-pair with the substrate RNA to form a helix 5 and wherein the said ribozyme can cleave and/or ligate the separate RNA(s) in trans.
Claims15
A Hairpin ribozyme lacking a substrate moiety, comprising between six and eight bases inclusive in helix 2 and able to base-pair with a separate substrate RNA, wherein said ribozyme comprises one or more bases 3' of helix 3 able to base-pair with said substrate RNA to form a helix 5 and wherein said ribozyme can cleave and/or ligate said separate substrate RNA in trans.
A trans-cleaving Hairpin ribozyme comprising between 6 and 8 bases inclusive in helix 2 lacking a substrate RNA moiety.
A trans-ligating hairpin ribozyme comprising between 6 and 8 bases in helix 2 lacking a substrate RNA moiety.
A Hairpin ribozyme having one or more bases 3' of helix 3 able to base-pair with a separate substrate RNA to form a helix 5.
Dependencies are inferred from the claim text.