Use of sialic acid or antibodies to sialidase as anti-infectious agents and anti-inflammatory agents
AssigneeThe United States of America as represented by the Secretary of the Army
InventorsAlan S. Cross, Daniel G. Wright, Peter Gomatos, Nicholas Stamatos
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Abstract
The administration of sialidase inhibitors or sialic acid is useful as me for treating inflammatory conditions and for intervening in infectious processes in instances where pathogenicity of the disease-causing organism is increased by microbial surface interaction with host cells.
Claims12
A method of treating inflammation by administration of an anti-inflammatory composition in dosage form comprising an anti-inflammatory effective amount of sialic acid or a sialic acid analogue of the formula:
- ##STR2## wherein R.sub.1,2,3 and 4 is H, alkyl, SO.sub.3 H, PO.sub.3 H.sub.2 or CO-alkyl, wherein alkyl has 1-4 carbons and may be substituted with OH, and R.sub.5 is CO-alkyl of 1-4 carbons which may be substituted with OH in a pharmaceutically acceptable carrier.
A method of treating inflammation by administration of an anti-inflammatory composition in dosage form comprising an anti-inflammatory effective amount 2,3-dehydro-2-desoxy-N-acetylneuraminic acid in a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.